Chelsea striker Diego Costa has withdrawn from the Spain squad for their European Championship qualifier with Macedonia
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Following the injury to Sergio Aguero fellow striker Alvaro Negredo will be the focal point of the Man City attack, but can he fire them to the top of the league.
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A second-half goal by Bernard Parker earned South Africa a shock 1-0 win over Euro and World champs Spain in the same stadium where La Roja won the 2010 World Cup.
Parker beat Victor Valdes after 57 minutes to stun Vicente del Bosque's side, which lost only its second game in more than three years.
Spain laboured their way to a narrow victory over Equatorial Guinea in an international friendly in Malabo thanks to first half goals from Santi Cazorla and Juanfran Torres.
However, the game will be remembered more for the aggressive challenges from the hosts than for the quality of football.
Vicente del Bosque has signed a contract extension to remain as Spain coach.
Del Bosque will continue at the helm of the reigning world and European champions until 2016. He said at a press conference today: "I can confirm that I have signed with the Spanish national team until 2016."
Barcelona's Marc Bartra knows he is entering a crucial phase of his career as he prepares to make his debut for the Spain national side.
– Barcelona defender Marc Bartra speaking to Marca
It is the biggest thing you can do as a footballer.
There are very good players (in the squad) but I have to be prepared to be ready at any time.
The most important thing when you get these dreams is to be consistent for much longer.
It's an important time for me with both Barcelona and Spain.
Spain will ditch their traditional blue shorts for the 2014 World Cup, where the reigning World and European Champions will be wearing an all-red strip.
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Atletico Madrid striker Diego Costa has received his first call-up to the Spanish national team.