Arsenal goalkeeper Wojciech Szczesny makes his first start in two months, coming in for Vito Mannone. Jack Wilshere returns from suspension in central midfielder and Theo Walcott also starts.
Tottenham boss Andre Villas-Boas opts to play two strikers for the first time in the Premier League - Jermain Defoe and Emmanuel Adebayor joining forces. Meanwhile there's a start for Hugo Lloris in goal, which may be a surprise given his howler against Maribor just over a week ago.
Arsenal XI: Szczesny, Sagna, Mertesacker, Koscielny, Vermaelen, Arteta, Wilshere, Cazorla, Walcott, Podolski, Giroud.
Spurs XI: Lloris, Walker, Vertonghen, Gallas, Naughton, Lennon, Sandro, Huddlestone, Bale, Defoe, Adebayor.