Phil Jagielka made a real hash of his clearance and the ball fell to Cristian Rodriguez, who belted a left-foot drive that flew an inch over.
Gary Cahill soon followed suit, making another poor clearance, but once again Uruguay could not capitalise.
A concerned Hodgson came to the edge of his technical area to bark orders to his players. It had little effect though as Uruguay continued piling on the pressure.
Cahill had to put in a last-ditch tackle to deny Edinson Cavani and the Paris St Germain man then clipped a shot just over the bar.
Godin was lucky to stay on the pitch when his outstretched arm hit Sturridge in the neck.
Then came Rooney's big chance of the first half. The striker connected with Gerrard's free-kick just under the goal frame, but his header struck the frame and bounced out.
Then, seven minutes before the break, Suarez struck.
Gerrard lost the ball on the halfway line while England had men upfield and Uruguay hit on the counter. Glen Johnson gave Cavani enough time and space to curl a peach of a cross that looped over Cahill's head and Suarez did the rest.
The Liverpool striker wheeled away before being mobbed by his team-mates.
England's defence again switched off after the break, allowing Cavani through, but luckily for the Three Lions, he shot wide.