The first fixture in Group F sees Iran take on Nigeria. Coached by Portuguese manager Carlos Quieroz, the Iranians will no doubt be relying on the quality of Fulham midfielder Ashkan Dejagah to see them overcome Nigeria. Meanwhile for Stephen Keshi's side, the hope that they can build on their African Cup of Nations success with victory in their opening group game.
Jozy Altidore ended his six-month goal drought by scoring twice for the United States in a 2-1 win over Nigeria.
If Nigeria's quick-breaking, counter-attacking style is to bear fruit in Group F, Ahmed Musa will probably need to have been on top of his game.
Stoke striker Peter Odemwingie has been including in Nigeria's 23-man squad for the World Cup but Sunday Mba has missed out after not showing enough "hunger", according to coach Stephen Keshi.
Uche Nwofor struck from an acute angle in the final minute to spare Nigeria's blushes as they began their World Cup preparation with a 2-2 draw against Scotland at Craven Cottage.
Nigeria's new World Cup shirts don't stray too far from their green-and-white kits of old.