There is a slight question mark hanging over Kun, having suffered three muscle injuries this season missing crucial parts of the campaign at the Etihad.
Speaking in the Argentine media, Aguero recently said about his injury issues and a potential relapse: “I do think to myself if something happens now, I will lose the rest of the Premier League season and the World Cup."
His record when he does play is unquestionable – Aguero has hit the back of the net 26 times in just 28 appearances this season, not an unsurprising stat considering his overall record since arriving at Manchester City is 73 goals in 116 matches.
Costing £38million in 2011, Aguero’s price has only gone up during his spell in the English top-flight, being one of the most consistent strikers in the Premier League, famously scoring the last-minute goal against QPR that won City the title in 2012, making him an eternal hero in East Manchester.
At international level, the 25-year-old former Atletico striker has 21 goals in his 47 caps, playing much of those games next to Messi - the Barcelona forward being a year older.
Argentina will focus on their strengths, attacking flair, with the likes of Real Madrid’s Angel Di Maria and Napoli’s Gonzalo Higuain all set to make the squad.
I think that after Cristiano Ronaldo and Leo Messi the third best striker is Sergio Aguero.
– Manuel Pellegrini on Sergio Aguero
Alejandro Sabella’s team will need all the firepower he can muster, considering the lack of defensive competence on show within his squad.
Possessing a low centre of gravity, ferocious power and tremendous speed, Aguero is a perfect foil for Messi, who can drop into space and able to find the critical final ball.
The South Americans, skippered by Messi, face a simple task to get out of the group, after being drawn against Bosnia, Iran and Nigeria – sides that should be easily beaten by team possessing the capabilities of Argentina.
“We know that we have a great team, but each match has to be played," Aguero said of his side.
“There doesn't exist any easy matches, but I think that with the squad that we have, there are chances. It depends on us.”
If they finish top of Group F, they will would play the runners-up from Group E, which would be one of France, Switzerland, Ecuador or Honduras, which won’t instil fear into Sabella’s men.
With this level of forward thrust, Argentina will test the best the world has to offer, and a good finish to the campaign with Manchester City could see Aguero and Messi both come into the tournament full of confidence, which will worry whoever the come up against, especially if they build momentum against the lesser nations they will face in the opening stages.