Liverpool survived a Manchester City onslaught to reach the Champions League semi-finals on a controversial night at the Etihad Stadium that saw Pep Guardiola sent off.
Luis Suarez scored his first Champions League goal of the season to earn Barcelona a 4-1 victory over Roma in the first leg of their quarter-final.
Liverpool drew significant first blood in their all-English Champions League quarter-final as Manchester City were blown away in 45 minutes in a raucous 3-0 Anfield defeat.
Cristiano Ronaldo scored twice, his second a brilliant overhead kick, as Real Madrid took a huge step towards the Champions League semi-finals with a 3-0 win against Juventus in Turin.
Bayern Munich made the most of several slices of good fortune to beat Sevilla and put themselves on course for the Champions League semi-finals.
Lionel Messi punished error-prone Chelsea as Barcelona advanced to the Champions League quarter-finals with a 3-0 win at the Nou Camp.
Manchester United's Champions League dreams are over after being rocked by Sevilla, with substitute Wissam Ben Yedder's brace securing a famous win against Jose Mourinho's lacklustre side.
Holders Real Madrid eased into the Champions League quarter-finals with a 2-1 win at 10-man Paris St Germain.