Business Secretary Vince Cable has urged shareholders in British banks to "get a stronger grip" on the boards and executives responsible for "systemic abuse".
He said that nobody at Barclays was prepared to take responsibility for the rate-rigging scandal that has engulfed the company in recent days and that shareholders ought to take action.
Mr Cable's comments came as Bob Diamond, the bank's embattled chief executive, prepares to face a panel of MPs over the controversy on Wednesday.
Ministers have also announced an independent review into the inter-bank lending rate in the wake of revelations that it was rigged by Barclays and other financial institutions.
Writing in an article for The Observer, Mr Cable said:
On Sunday morning, Lord Turner, chairman of the Financial Services Authority, told BBC1's Andrew Marr Show that "people are justifiably angry at some of the practices that were present in particular in the run-up to the financial crisis in 2008".
He said there had already been "significant steps" to prevent the Libor scandal happening again and that he did not believe similar behaviour was taking place now.
But he also said the law should be tightened to tackle banking misbehaviour.
Barclays' boss Bob Diamond is facing growing demands for his resignation in the wake of the scandal and there appeared to be moves by investors against the bank's chairman, Marcus Agius.
Both are to be questioned by the Treasury Select Committee this week.
The government said the independent review will consider the future operation of the so-called Libor rate and the possibility of introducing criminal sanctions for its manipulation.The move did not satisfy Labour, however, whose leader Ed Miliband insisted the public would not accept anything less than a full-scale independent inquiry into the culture and practices of banking.
His call came after the Financial Services Authority uncovered "serious failings" in the sale of complex financial products to small businesses, just days after the rate-rigging affair emerged at Barclays.
Taxpayer-backed Royal Bank of Scotland has also confirmed it is being investigated for manipulating the rates at which banks lend to each other.
Treasury sources said its review, to be headed by an as-yet-undisclosed independent figure, would ensure a speedy response to the issue, resulting in amendments to the Financial Services Bill this summer.
Ministers are considering setting up a separate review into the professional standards of bankers.
On Saturday, Prime Minister David Cameron said the Government would ensure "the criminal law can go wherever it needs to".
Asked about calls for a wide-ranging inquiry, he said: "Let's take our time, think this through carefully... That's what I'm determined to do, and that's what we will do."
But the Labour leader Mr Miliband said the Prime Minister was "out of touch" and warned that voters would not accept "the establishment closing ranks".
He called for an inquiry along the lines of Lord Justice Leveson's into media ethics and practices.
He told a Fabian Society conference in London.
Barclays was fined £290 million by UK and US regulators for manipulating the rate at which banks lend to each other in the first of two scandals to rock the City this week.
On Friday, the FSA revealed separately that Barclays, HSBC, Royal Bank of Scotland and Lloyds Banking Group had agreed to pay compensation to customers who were mis-sold interest-rate hedging products.
Some 28,000 of the products have been sold since 2001 and may have been offered as protection - or to act as a hedge - against a rise in interest rates without the customer fully grasping the downside risks.
Serious Fraud Office investigators are in talks with the regulator over the scandal.