Oscar Pistorius will serve part of his five-year sentence at the Kgosi Mampuru II prison in central Pretoria.
The facility reportedly holds some 7,000 inmates including just over 100 with disabilities.
The acting national commissioner of correctional services, Zach Modise, indicated during Pistorius' sentencing that he will be held in the hospital wing.
Unlike the rest of the facility, this area has single cells and extra facilities such as showers.
Judge Thokozile Masipa also indicated that Pistorius would be entitled to some alterations including hand rails to aid his mobility in his cell.
Like other inmates, he is likely to wear orange, loose-fitting trousers and a shirt bearing the Correctional Services logo.
Within the first six hours of arriving at the prison, Pistorius will have an assessment to establish his health and special needs.
He will also have access to a prison doctor and a limited number of psychologists who may offer him on-to-one or group therapy.
As a high-profile prisoner, Pistorius is bound to attract attention, but Mr Modise insisted that gang violence is less of an issue than has been reported in the local media.
Pistorius' defence team drew attention newspaper reports that a notorious gang leader had threatened to "take out" the athlete if he became an inmate.
Kgosi Mampuru II is one of South Africa's most famous correctional facilities, having been the site of numerous hangings during the apartheid era.
It was renamed last year after a tribal leader who has executed at the facility in 1883 for public violence and revolt against the government.