Drinking a large glass of wine is the equivalent to downing three shots of vodka, the head of Public Health England has warned.
Duncan Selbie said alcohol was fast becoming the "silent killer" of working age adults in Britain because many people "pour a glass and have no idea how much they are drinking".
A 250ml glass of wine with an alcohol volume of 12.5% contains three units, according to the NHS, while one small single shot of vodka with an volume of 40% is the equivalent of one unit.
Selbie said that deaths in working age people from liver disease have increased by 500% since the 1970s as a result, making it the third biggest killer of people in this group.
He said 75% of people with cirrhosis are only diagnosed once they are admitted to hospital.
Selbie said the illness was "largely preventable" but alcohol, one of three risk factors along with obesity and viral hepatitis, was difficult to control.
"For example, a large glass of wine is like three shots of vodka, so it is very easy for people to pour a glass and have no idea how much they are drinking," he wrote in a weekly briefing to staff.
Mr Selbie's comments were based on research by Professor Julia Verne, who is clinical head for liver disease for PHE.
MPs have said that people should be encouraged to enjoy a drink in their local pub instead of buying wine at "rock bottom prices" in supermarkets living room as it is easier to keep track of their drinking.
Conservative MP Tracy Crouch, the former chair of the alcohol misuse group, told The Telegraph that people needed to become more aware of the dangers of their drinking habits.