"Everyone is entitled to their own opinion, but not to their own facts", said fact-checking organisation Full Fact of ITV's EU referendum debate.
"Thursday's panel took that message to heart, challenging one another over the basic factual building blocks of the opposing cases".
Debating fiercely for the Remain campaign were SNP leader Nicola Sturgeon, shadow business secretary Angela Eagle and Energy and Climate Change secretary Amber Rudd.
Meanwhile, former London Mayor Boris Johnson, former minister Andrea Leadsom and Labour MP Gisela Stuart urged the public to "take back control" and vote in favour of Brexit.
Analysis of Remain and Leave's claims
Fact check round-up: Vote leave claims
Fact check round-up: Vote remain claims