Southampton will assess forward Jay Rodriguez ahead of Sunday's Premier League match against Swansea.
Rodriguez came off the bench to score a last-minute goal in the 3-0 Europa League win over Sparta Prague on Thursday evening, and manager Claude Puel reported him as a fitness concern.
Puel made seven changes for the European tie, so the likes of Charlie Austin, who scored twice, and midfielder James Ward-Prowse could be back on the bench. Club-record signing Sofiane Boufal remains out with a knee injury, as does right-back Jeremy Pied.
Swansea are set to return to a four-man that could mean more disappointment for Neil Taylor.
The Wales international was hauled off before half-time of the 2-2 draw against Chelsea last weekend as manager Francesco Guidolin abandoned the experiment of playing three central defenders. Taylor could once again lose out to Stephen Kingsley, who has been first-choice left-back this season, at St Mary's.
Record signing Borja Baston could make the bench after a thigh injury which has delayed his debut since a £15.5million move from Atletico Madrid, but winger Nathan Dyer has been ruled out for two months with an ankle problem.
Southampton squad: Forster, Soares, Van Dijk, Fonte, Bertrand, Davis, Romeu, Clasie, Tadic, Redmond, Rodriguez, McCarthy, Austin, Targett, Yoshida, Hojbjerg, Ward-Prowse, Long, Martina.
Swansea squad: Fabianski, Naughton, Amat, Fernandez, Kingsley, Cork, Fer, Ki, Routledge, Barrow, Sigurdsson, Llorente, Nordfeldt, Rangel, Taylor, Mawson, van der Hoorn, Montero, Fulton, McBurnie, Borja.