Plymouth took advantage of a rare slip-up by leaders Doncaster to move to within five points of the Sky Bet League Two summit.
Rovers had yet to drop a point in 2017 ahead of their home clash with Morecambe but they were left frustrated by the visitors as they shared a 1-1 draw.
Peter Murphy gave the visitors a first-half lead and they earned a share of the spoils despite John Marquis levelling with more than half an hour remaining.
Plymouth went into their game at Cambridge smarting from a shock defeat by Yeovil and they got back on track with a 1-0 victory courtesy of Antoni Sarcevic's first goal for the club just before the break.
Third-placed Carlisle came from behind to beat relegation-threatened Leyton Orient 2-1, Gary Liddle and Jamie Proctor - who was later sent off - scoring the goals after Gavin Massey had given the hosts the lead.
Exeter remain in contention for an automatic promotion spot after making it seven straight victories on Saturday.
Jordan Moore-Taylor gave the Grecians an early lead before a David Wheeler double and Lloyd James' strike secured a 4-0 triumph for the hosts against Crewe, who lost Charlie Kirk to a red card late on.
Scott Kashket got the only goal as Wycombe leapfrogged Portsmouth in the play-off places, while Danny Hylton missed a stoppage-time penalty for fifth-placed Luton in a 1-1 draw at Grimsby, where the visitors' Isaac Vassell cancelled out Chris Clements' header.
Mansfield are just two points behind Portsmouth after a 2-0 win at Barnet, Ben Whiteman breaking the deadlock before Shaquile Coulthirst wrapped up the three points from the penalty spot.
Kurtis Guthrie cancelled out Jamille Matt's close-range strike for Blackpool as play-off hopefuls Colchester earned a 1-1 draw in the north-west.
Goals from Harvey Rodgers and Noor Husin gave Accrington a 2-0 victory over fellow strugglers Notts County and two goals in the last 14 minutes from Matt Godden gave Stevenage a 2-1 win at Crawley, who had led through James Collins' penalty.
Matt Dolan's spot-kick quickly cancelled out Padraig Amond's opener as Yeovil earned a 1-1 draw at Hartlepool, while Jaanai Gordon's stoppage-time goal stole a point for rock-bottom Newport against Cheltenham, for whom Kyle Wootton opened the scoring.