Elliot Daly will start England's non-cap international against the Barbarians at full-back with Danny Cipriani forced to settle for a place among the replacements.
It is Daly's first outing in the number 15 jersey having made all but one of his 18 previous England appearances on the wing and the selection sees Mike Brown - the usual incumbent in the position - switch to the left wing.
"It's a great opportunity to play Elliot there, we've always wanted to play him there and this is the right time," head coach Eddie Jones said.
"He's got speed, he's got a big left foot and good game sense. It's also a great opportunity for Mike Brown to show his versatility."
Cipriani has been overlooked for a starting role despite his return to the senior England squad for the first time under Jones.
The 30-year-old has been in irresistible form for Wasps this season and will tour South Africa next month, but will be limited to a cameo at Twickenham with Jones refusing to disclose whether he is being considered at fly-half or full-back.
"Danny is one of 34 players who we've had in camp," Jones said.