AFC Bournemouth v Man Utd - Saturday 12:30pm
Bournemouth captain Simon Francis is a doubt for the home game against Manchester United.
The defender is nursing a slight groin problem following the Carabao Cup win over Norwich in midweek. A scan on the injury has shown no serious damage and Cherries boss Eddie Howe will make a late decision on Francis' fitness.
Joshua King will remain absent. The Norwegian forward has missed the last two games with an ankle injury and will not be ready to return against his former club.
Antonio Valencia, Marouane Fellaini and Diogo Dalot remain absent for United's trip to the south coast.
United captain Valencia has been absent for a month, with manager Jose Mourinho confirming a knee injury will keep him out of Saturday's trip to the south coast.
Fellaini and Dalot remain out with injuries sustained during the international break, but Jesse Lingard and Alexis Sanchez are back to full fitness. United boss Mourinho did not provide an update on Phil Jones, who last featured for the club on September 25.
Cardiff City v Leicester City - Saturday 3:00pm
Cardiffwelcome back Harry Arter for Leicester's emotional Premier League visit to the Welsh capital.
Arter has recovered from an ankle injury which forced him to miss the 4-1 defeat at Liverpool last weekend, but Jazz Richards is out with a knock picked up in training.
Joe Ralls completes a three-match ban as Leicester return to action for the first time since the death of owner Vichai Srivaddhanaprabha and four others in a helicopter crash last weekend.
Daniel Amartey will miss the foxes trip to south Wales - the Foxes' first match since the helicopter crash which killed club owner Vichai Srivaddhanaprabha.
The 23-year-old midfielder suffered a serious ankle injury during the home draw with West Ham last weekend and he is set to be sidelined for around four months after undergoing surgery.
Captain Wes Morgan is available again after serving a ban while Matty James resumed training this week after a long-term Achilles problem.
Everton v Brighton - Saturday 3:00pm
Everton defenders Phil Jagielka and Jonjoe Kenny will both miss the visit of Brighton.
The pair are carrying minor injuries but manager Marco Silva expects both to resume training next week.
Winger Ademola Lookman is pushing for his first Premier League start of the season.
Brighton remain without Davy Propper and Pascal Gross for the trip to Goodison Park.
Both are short of fitness following ankle injuries, with the influential Gross having been out since September 1. The club are confident both will be available after the international break.
Newcastle v Watford - Saturday 3:00pm
Newcastle defender Ciaran Clark will miss Saturday's Premier League clash with Watford.
The Republic of Ireland international, who had earlier recovered from a thigh injury, was laid low by a bug earlier this week and although he has returned to training, he is not in the squad for the game at St James' Park.
Fellow defender Florian Lejeune remains the only senior casualty, although he is making good progress in his recovery from cruciate ligament surgery.
England midfielder Nathaniel Chalobah is set to return to the Watford squad from a minor knee problem.
Forward Troy Deeney, though, remains a doubt as he recovers from a hamstring injury.
Defenders Sebastian Prodl (leg) and Daryl Janmaat (knee) are also still sidelined, along with midfielder Tom Cleverley (Achilles).
West Ham United v Burnley - Saturday 3:00pm
West Ham remain without suspended skipper Mark Noble for the visit of Burnley.
Boss Manuel Pellegrini will hand left-back Aaron Cresswell a late fitness test on a groin problem.
Jack Wilshere and Andy Carroll (both ankle) are due back after the international break but Andriy Yarmolenko, Carlos Sanchez, Manuel Lanzini and Winston Reid are long-term absentees.
Aaron Lennon is available for the game at the London Stadium, while Jack Cork faces a late fitness test.
Winger Lennon has recovered from the sickness bug that ruled him out of last Sunday's 4-0 loss to Chelsea, a game that saw midfielder Cork come off with an ankle problem.
Defender Ben Gibson (hernia) will definitely not be involved at the London Stadium on Saturday, along with left-back Stephen Ward (knee) and goalkeeper Nick Pope (shoulder).
Arsenal v Liverpool - Saturday 5:30pm
Unai Emery could be unable to call upon a host of defenders as Arsenal welcome Premier League rivals Liverpool to the Emirates Stadium on Saturday.
Hector Bellerin (thigh) is being assessed ahead of the game alongside fellow full-backs Nacho Monreal and Sead Kolasinac - who are both recovering from hamstring issues - and Sokratis Papastathopoulos (ankle).
Laurent Koscielny is still not up to speed following an Achilles injury, while midfielder Matteo Guendouzi is suspended and Mohamed Elneny (thigh) is also missing.
Liverpool midfielders Naby Keita and Jordan Henderson will not be available for clash between top four rivals
Both are only scheduled to return to training over the next couple of days after hamstring injuries but could come into contention next weekend.
Andrew Robertson is set to return at left-back after being rested last weekend.
Wolves v Tottenham Hotspur - Saturday 7:45pm
Diogo Jota is out of Wolves' clash with Tottenham at Molinuex.
The forward is sidelined with a minor problem, although boss Nuno Espirito Santo refused to reveal the exact issue.
Jota was a substitute in last week's 1-0 defeat to Brighton, meaning Wolves may yet be unchanged.
Tottenham will be without Eric Dier and Danny Rose at Wolves.
The England pair have respective thigh and groin injuries and will not play before the international break.
Victor Wanyama (knee) and Jan Vertonghen (hamstring) continue to miss out.
Manchester City v Southampton - Sunday 3:00pm
Champions Manchester City are without midfielder Kevin De Bruyne for the visit of Southampton in the Premier League on Sunday.
The Belgium playmaker suffered knee ligament damage in Thursday's Carabao Cup win over Fulham and could be out for up to six weeks.
Defender Nicolas Otamendi is out with a tendon problem but midfielder Ilkay Gundogan is close to returning after a hamstring injury.
Southampton expect to have Pierre-Emile Hojbjerg available for the trip to City.
The Danish midfielder has resumed full training after missing the goalless draw with Newcastle through illness.
Saints boss Mark Hughes otherwise reported no fresh injury problems.
Chelsea v Crystal Palace - Sunday 4:00pm
Eden Hazard should be fit to play some part in Chelsea's Premier League clash with Crystal Palace on Sunday.
The Belgium forward has been struggling with a back injury, but took part in full Chelsea training for the first time in two weeks on Thursday.
Blues boss Maurizio Sarri has yet to decide whether the 27-year-old will be ready to feature from the start.
Crystal Palace again have James McArthur, Wilfried Zaha and Cheikhou Kouyate available following knocks.
Their availability for Sunday's fixture at Chelsea comes with Connor Wickham having been ruled out with a thigh strain, the same injury that means Joel Ward also misses out.
Wickham's absence means they again have few options up front, with Christian Benteke continuing his recovery from knee surgery.
Huddersfield v Fulham - Monday 8:00pm
Defender Terence Kongolo is among the players who could return to action in Huddersfield's Premier League home clash with Fulham on Monday.
Terriers boss David Wagner has said it looks as if all his players are in contention apart from midfielder Danny Williams (knee).
Kongolo (hamstring) and Tommy Smith (knee), both missing for the last three matches, have been back in training, as have Rajiv van La Parra and Abdelhamid Sabiri after illness.
Fulham midfielder Kevin McDonald will return to contention for the game on Monday evening.
McDonald missed Thursday's Carabao Cup defeat to Manchester City due to suspension after being sent off against Bournemouth last weekend.
Defender Joe Bryan remains unavailable because of a hamstring injury.