Joe Cokanasiga will make his England debut as one of 11 changes in personnel made for Saturday's Test against Japan at Twickenham.
The giant Fijian-born wing, who turned 21 today, has been in destructive form for Bath this season and is rewarded with his first cap in a team that is captained by George Ford.
Only full-back Elliot Daly starts the penultimate Quilter International in the same jersey, with wing Chris Ashton, lock Maro Itoje and flanker Mark Wilson surviving but switching positions.
A new-look centre pairing of Jack Nowell and Alex Lozowski plays outside Ford and his half-back partner Danny Care.
Dylan Hartley and Owen Farrell, co-captains for the first two games of the autumn against South Africa and New Zealand, are present on the bench.
Hartley is replaced by British and Irish Lion Jamie George at hooker as part of an all-new front row also featuring Exeter duo Alec Hepburn and Harry Williams.
Charlie Ewels joins Itoje in the second row, Courtney Lawes is drafted in at blindside flanker and Zach Mercer wins his second cap at number eight, with Wilson switching to openside.
Jones has made the changes with the four-day turnaround between group games against Tonga and the United States at next year's World Cup in mind.
"This weekend is a good opportunity for us to test the depth of the squad," Jones said.
"A number of players have changed their roles going from finishers to starters and starters to finishers so that is the essential change to the squad.
"It is exciting to be able to give starting opportunities to Zach Mercer and Joe Cokanasiga and young Ted Hill on the bench."
England team to face Japan:
Daly; Cokanasiga, Nowell, Lozowski, Ashton: Ford, Care; Hepburn, George, Williams, Ewels, Itoje, Lawes, Wilson, Mercer.
Replacements: Hartley, Moon, Sinckler, Hill, Underhill, Wigglesworth, Farrell, Slade.