Severe peanut allergy could be overcome by building up tolerance according to study

Peanut allergy sufferers have been given new hope following the results of a landmark study.

Children diagnosed with a severe allergytook part in a trial where they were given increasing amounts of peanut protein over a year.

Emily Pratt who was "extremely allergic" to peanuts had a successful outcome from the trial.

Her mother, Sophie, told ITV News the trial had "transformed" their lives: "One thing I had never realised was traces of nuts and peanut can be found all over the place, so we found out that Emily was extremely allergic -so less than a third of peanut could make her go into Anaphylaxis".

She said the trial had "transformed" their lives.

The trial found that participants not normally able to tolerate exposure to even a tenth of a single peanut could eventually cope with two whole peanuts.

It is believed that by gradually building up tolerance levels, allergy sufferers could protect themselves from accidental exposure.

Sophie Pratt whose daughter was

Researchers from Evelina London Children’s Hospital and King’s College London took part in a study which suggests immunotherapy treatment, already used to treat pollen and bee sting allergies, could protect people from life-threatening reactions.

The PALISADE study recruited nearly 500 children aged four to 17 from the US and Europe to take part in the largest-ever peanut allergy treatment trial.

Participants were split into groups who received either a capsule of peanut protein or a dummy powder.

Doses were gradually increased every two weeks for a period of six months, before continuing on a “maintenance dose” of peanut for a further six months.

However, Paediatric Allergy Consultant George Du Toit warned against people trying this method at home.

He told ITV News: "The very first doses are extremely small you wouldn't accurately be able to measure this yourself so you wouldn't want to measure this on a micro-scale at home".

Paediatric Allergy Consultant George Du Toit warned against people trying the trial at home.

The results, published in the New England Journal of Medicine, found about two-thirds (67%) of children and teenagers could tolerate at least 600mg of peanut protein, compared with just four per cent of participants on the dummy placebo.

Professor George du Toit, paediatric allergy consultant at Evelina London and the study’s chief investigator, said: “Peanut allergy is extremely difficult to manage for children and their families, as they have to follow a strict peanut-free diet.

“Families live in fear of accidental exposure as allergic reactions can be very severe, and can even lead to death.

“Until recently there has been nothing to offer peanut allergy suffers other than education around peanut avoidance and recognition and self-treatment of allergic reactions.”

Sophie Pratt, 44, from Kentish Town in north London, enrolled her six-year-old daughter Emily, who has had a peanut allergy since she was one, on the study.

“The study has completely changed our lives,” she said. “Before Emily took part we were uncomfortable being more than twenty minutes away from a hospital and she wasn’t able to attend play dates or parties without me or my husband being there.

“We had to constantly study food labels to ensure peanuts were completely eliminated from Emily’s diet. Her allergy was very severe so even a small amount of peanut could lead to a very serious reaction. The impact on our family life was huge.”

Ms Pratt said by the end of the year-long trial Emily was able to tolerate around seven peanuts.

Peanut allergy, a potentially life-threatening condition, has doubled over the last two decades and affects about 1 in 50 children in the UK.

The allergy is rarely outgrown and is the most common cause of food allergy deaths.

The PALISADE study was funded by Aimmune Therapeutics, which manufactures the peanut protein used during the trial.