Olivia Colman, Richard Madden and Christian Bale were among the Brits to triumph at the Golden Globes, where Bohemian Rhapsody and Green Book were the big winners of the night.
Broadchurch star Colman took home the best actress in a comedy or musical prize for her role as Queen Anne in black comedy The Favourite.
Madden won the best actor in a TV drama prize for his role in Bodyguard, while Bale scored the best actor in a musical or comedy for his portrayal of the former vice-president Dick Cheney in Vice, thanking "Satan" for inspiring him in the role.
Ben Whishaw was honoured in the best supporting actor in a limited series or TV movie category for playing Norman Scott in A Very English Scandal.
Picking up her award, Colman said: "Cor blimey, thank you so much. I'm not going to cry because my entire table will point and laugh at me as I've been crying all evening."
She thanked her co-stars Emma Stone and Rachel Weisz, saying: “Every second of working with you was such a joy and I was so sad that it finished.
“I would like to tell you how much working on this film meant to me but I can’t remember because I’m too excited.”
She added: “I went on a private jet and I ate constantly through the film and it was brilliant and I promise I will keep on enjoying this, because it’s amazing.”
Scottish star Madden paid tribute to the cast and crew of BBC hit Bodyguard as he collected his prize, including co-star Keeley Hawes and writer Jed Mercurio.
He said: “I didn’t see this coming at all, I wouldn’t be here at all if it wasn’t for the amazing cast and crew who worked really hard and thank you to Keeley Hawes, who is the best actress I could ever work with, who is amazing and generous.”
At the ceremony in Los Angeles, he also had a few words for his parents: “Mum and dad, who flew all the way from Scotland, I wouldn’t be here without you.”
Bale thanked his director, Adam McKay, joking that the filmmaker chose him because he thought “I have got to find someone who can be completely charisma-free and reviled by everyone, it’s got to be Bale”.
He joked he would play Senate majority leader Mitch McConnell next, adding: “Thank you Satan, for giving me inspiration for this role.”
Meanwhile Whishaw, who played Norman Scott in A Very English Scandal, thanked the BBC for continuing to make “idiosyncratic and powerful work”, as well as his co-star Hugh Grant and writer Russell T Davies as he collected his gong.
He dedicated the award to Scott, praising him for “taking on the establishment with a courage and a defiance that I find inspiring,” calling him “a true queer hero and an icon”.
Bohemian Rhapsody was the big winner of the night, scooping the prize for best drama and best actor, which was awarded to Rami Malek for his portrayal of Freddie Mercury.
“I am beyond moved, my heart is pounding out of my chest right now," Malek said.
Addressing his castmates, he said: “I am going to tackle you in a moment, I am going to jump all over you guys.”
He also thanked Queen and the band’s late frontman, saying: “Thank you to Freddie Mercury for giving me the joy of my lifetime. I love you, you beautiful man. This is for – and because of – you, gorgeous.”
There was also triumph for Green Book, which won best musical or comedy, best screenplay and best supporting actor for Mahershala Ali.
Glenn Close triumphed in the best actress in a drama category for The Wife, while Regina King won best supporting actress for If Beale Street Could Talk.
It was a disappointing night for A Star Is Born, with Lady Gaga and Bradley Cooper losing out in the acting categories, while Cooper missed out on the directing prize to Roma filmmaker Alfonso Cuaron.
The film’s only win was best original song, for Shallow, which was collected by Lady Gaga and Mark Ronson.
Gaga told the packed ballroom at the Beverly Hilton: “I just want to say as a woman in music it is really hard to be taken seriously as a musician and as a songwriter, and these incredible men lifted me up and supported me.”
The ceremony was hosted by Sandra Oh and Andy Samberg, who largely stayed away from political topics.
The pair joked they had been chosen to host due to being the only people left in Hollywood who haven not got in trouble for “saying something offensive”.
While last year’s ceremony saw the majority of women wearing black for the launch of the Time’s Up movement for gender equality, this year a smaller number of women wore wristbands for Time’s Up X 2, encouraging companies to double the number of women in decision-making positions.
Oh also enjoyed a moment at the winner’s podium, as she collected the gong for best actress in a TV drama for Killing Eve and thanked her parents in Korean before bowing to them.
The show, penned by Briton Phoebe Waller-Bridge, was also nominated for best drama series, alongside Bodyguard, but lost out to The Americans, who finally picked up the prize for its final series.
Elsewhere in television, Michael Douglas won best actor in a TV comedy for his Netflix series The Kominsky Method, which also took the best TV comedy prize.
And Rachel Brosnahan was named best actress in a TV comedy for The Marvellous Mrs Maisel.
Full list of winners:
Best Actor, TV Musical or Comedy - Michael Douglas
Best Motion Picture, Animated - Spider-Man: Into the Spiderverse
Best Actor, TV Series Drama - Richard Madden, Bodyguard
Best TV Series Drama - The Americans
Best Supporting Actor, Limited Series/TV movie/Series - Ben Whishaw, A Very English Scandal
Best Actress, Limited Series/TV movie - Patricia Arquette - Escape at Dannemora
Original Song, Motion Picture - Shallow, A Star Is Born
Best Supporting Actress, Motion Picture - Regina King, If Beale Street Could Talk
Best Actress, TV Series Drama - Sandra Oh, Killing Eve
Best Supporting Actor Motion Picture - Mahershala Ali, Green Book
Best Screenplay - Green Book
Best Supporting Actress, Series/Limited Series/TV Movie - Patricia Clarkson, Sharp Objects
Best Actor, Musical or Comedy - Christian Bale, Vice
Best Motion Picture Foreign Language - Roma
Best Actor, Limited Series Or TV Movie - Darren Criss, The Assassination of Gianni Versace: American Crime Story
Best Director, Motion Picture - Alfonso Cuaron, Roma
Best Actress, TV Series Musical Or Comedy - Rachel Brosnahan, The Marvelous Mrs Maisel
Best TV Series, Musical or Comedy - The Kominski Method
Best Limited Series/TV Movie - The Assassination of Gianni Versace: American Crime Story
Best Actress, Motion Picture Drama - Olivia Colman, The Favourite
Best Motion Picture, Musical Or Comedy - Green Book
Best Actress, Motion Picture Drama - Glenn Close, The Wife
Best Actor, Motion Picture Drama - Rami Malek, Bohemian Rhapsody
Best Motion Picture Drama - Bohemian Rhapsody