Barbara Broccoli, who has worked on the films for more than four decades, made the comments amid mounting speculation over the gender of the next 007.
There have been calls for the spy to be portrayed by a female actor, after only being played by men since the first release in 1962.
Speaking to Variety magazine, Bafta winning director Broccoli said: "He can be of any colour, but he is male."
"I believe we should be creating new characters for women - strong female characters; I'm not particularly interested in taking a male character and having a woman play it."
"I think women are far more interesting than that," she added.
The comments come just months before the release of the next film, No Time To Die, which has already had Daniel Craig confirmed as being at the helm for the final time.
No details have been given over who could replace Craig as Bond.
With no licence to kill, the spy is taking a well-earned break; but that peace doesn't last long.