Video report by ITV News Correspondent Rachel Younger
It comes as the Government announced unprecedented measures to cover the wages of workers who would otherwise lose their jobs due to the outbreak.
Boris Johnson said a number of venues, including nightclubs, theatres, and leisure centres should close their doors from Friday night to slow the spread of Covid-19 and prevent the NHS coming under unsustainable pressure.
He was followed by the Chancellor who said the Government would for "the first time of our history [...] step in and help pay people's wages."
Rishi Sunak announced Government grants will cover 80 per cent of the salary of "retained workers up to a total of £2,500 a month".
Mr Sunak added: "Our planned economic response will be one of the most comprehensive in the world.
"To all those at home, right now anxious about the days ahead, I say you will not face this alone."
Announcing the closure of a number of services across the UK, Boris Johnson said the measures were needed to reduce "unnecessary" social gatherings by 75 per cent in order to have an impact on the infection rate.
The Prime Minister said: The speed of our eventual recovery depends entirely on our collective ability to get on top of the virus now and that means we have to take the next steps on scientific advice.
"We need now to push down further on that curve of transmission between us."
What is social distancing and how do I do it?
Mr Johnson said that the Government does not want to immobilise major transport networks: "Transport is fundamental to our ability to deliver vital public services.
"I was pretty clear that we don’t want, for instance, to immobilise the Tube or our major transport networks."
"It’s just too important for the delivery of crucial public services."
ITV's Business and Economics Editor Joel Hill on how businesses have reacted to the government's plans.
Announcing the latest measures, Mr Johnson said the Government would be continually assessing the situation around the requested closures "to see if we can relax any of these measures".
Mr Sunak said the Government was deferring the next quarter of VAT payments for businesses until the end of June.
He said the move represented a direct cash injection of more than £30 billion.
The Universal Credit standard allowance will also be increased for the next 12 months by £1,000 a year, the Chancellor announced.
The chain said it would close all its pubs on Friday night.
While the Campaign for Real Ale (Camra) welcomed the move. Chairman Nik Antona said:
"Whilst the pubs industry will be devastated by the decision to force closure, it is exactly the type of decisive leadership that has been called for this week as many pubs hung in limbo."
The group added, however, that it was "concerned" by the lack of guidance for "the British independent brewing industry".
Camra said the industry "needs to be protected and supported if they are to continue to contribute so much to their local and the national economies."
The Prime Minister also reminded the public they are "not invincible" and asked individuals to resist the temptation "to go out tonight".
He added: "You can still be a carrier of the disease and pass it on."
Deputy chief medical officer Dr Jenny Harries added the Government was not saying "don’t go outside.
"We are saying, if you are going to go outside, go in a way that reduces your social contact".
The new measures were welcomed by Mayor of London Sadiq Khan who said he agreed with the decision to shut pubs, restaurants and other public spaces.
He tweeted: "I want to make a direct appeal to everyone: Act immediately on the expert advice. If you ignore this, people will die as a result."
Coronavirus: Everything you need to know