The moment will be streamed live by ITV News on all our social media channels.
Organisers of the "Clap For Carers" campaign - which started online - say it is being staged because "during these unprecedented times they [NHS staff] need to know we are grateful".
The Wembley Arch, the Principality Stadium, the Royal Albert Hall and Lincoln Cathedral are said to be among some of the landmarks which are set to be lit up in blue during the salute.
It is part of the #lightitblue campaign which has been organised by members of the events and entertainment industry as a way to say thank you.
People on lockdown across Europe applaud medical staff working through the coronavirus pandemic:
Presenters Chris Moyles and Kate Garraway are among the high profile figures who have said they are backing the campaign.
Radio X presenter Chris Moyles rallied his listeners to "make some noise for the thousands and thousands of people [in the NHS] that we'll probably never meet, just to say 'thank you' for everything they are doing for us".
Jointly founders of the #lightitblue campaign - Gary White and Chuck Crampton - said that all venues will use existing LED technology to create a flash of blue on facades and screens.
In a statement, organisers said: "The events and entertainment industry finds itself in an unprecedented state of enforced inaction.
"The best thing we can do - apart from staying at home - is to use our skills and networks to say thank you to everyone who is supporting the NHS and risking their own health to help others during this pandemic."
Coronavirus: Everything you need to know