An antibody treatment that could lessen the impact of Covid-19 is to be trialled on patients in UK hospitals.
Monoclonal antibodies, which are laboratory-made and strong, will be given to about 2,000 people to see if they are effective against coronavirus.
It forms part of the UK Recovery Trial, which in June found that a cheap steroid called dexamethasone could save the lives of people with severe Covid infection.
The first patients will be given the new drugs in the coming weeks.
The Recovery trial, co-ordinated by the University of Oxford, will assess the impact of giving patients REGN-COV2 alongside usual standard care to see if it lessens the severity of coronavirus and can reduce deaths.
In the new phase 3 study, at least 2,000 patients will be randomly allocated to receive REGN-COV2 plus usual care, and the results will be compared with at least 2,000 patients not on the therapy.
REGN-COV2, which was created by the US firm Regeneron, is made up of two monoclonal antibodies (REGN10933 and REGN10987).
Today’s news is another promising step in the search to find effective treatments, which will improve our ability to deal with this destructive virus
These are man-made antibodies (proteins in the blood which attack viruses and bacteria) which act like human antibodies in the immune system.
When coronavirus infects your body, antibodies attach to the spikes on the outside of the virus, blocking it from entering your cells.
In order to produce monoclonal antibodies, scientists search through them to find which is best at attaching to the spike - in this case on the outside of the coronavirus - and then multiply it in the lab to produce huge quantities.
This is then given to patients, immediately boosting their immune response.
In this case, the cocktail of drugs targets two components in the spike protein of the Covid-19 virus with the aim of interrupting its ability to infect.
Peter Horby, professor of emerging infectious diseases and global health at the University of Oxford and chief investigator of the trial, said: "We have already discovered that one treatment, dexamethasone, benefits Covid-19 patients, but the death rate remains too high so we must keep searching for others.
Novel antivirals and monoclonal antibodies are among the most exciting and promising treatments for Covid-19 because they are specific to the disease
"The Recovery trial was specifically designed so that when promising investigational drugs such as REGN-COV2 became available they can be tested quickly."
He added: "We are looking forward to seeing whether REGN-COV2 is safe and effective in the context of a large-scale randomised clinical trial.
“This is the only way to be certain about whether it works as a treatment for Covid-19.”
Nick Cammack, who is leading Covid-19 therapeutics work for Wellcome (a health research-based charity), said: "Novel antivirals and monoclonal antibodies are among the most exciting and promising treatments for Covid-19 because they are specific to the disease, but they are also traditionally the most expensive.
"Large-scale randomised controlled studies like Recovery give us the best understanding of whether drugs like REGN-COV2 are safe and effective against Covid-19, but we must ensure that any successful treatment is available to everyone who needs it globally."
England’s deputy chief medical officer, Professor Jonathan Van-Tam, said: "Today’s news is another promising step in the search to find effective treatments, which will improve our ability to deal with this destructive virus, and a testament to the confidence that others around the world have in this brilliantly conceived and executed trial.
"I look forward to seeing how REGN-COV2 performs in clinical trials, and I urge people to volunteer in this research which could ultimately save many lives," he added.
The new trial will tell us whether antibodies that attack the virus can be an effective treatment for Covid-19
Professor Fiona Watt, executive chair of the Medical Research Council, said: "Monoclonal, or targeted, antibodies are already used to treat cancer and autoimmune diseases.
"The new trial will tell us whether antibodies that attack the virus can be an effective treatment for Covid-19."
Regeneron has linked up with the pharmaceutical giant Roche to increase the global supply of REGN-COV2 if it proves effective.
The firm said that studies in animals have shown the cocktail can reduce the amount of virus and damage to the lungs.
Martin Landray, professor of medicine and epidemiology at the University of Oxford, said: "Up to now, we have largely been studying whether existing drugs can be repurposed to tackle this new disease, but we now have the opportunity to rigorously assess the impact of a drug specifically designed to target this coronavirus."