The long-running space adventure has so far produced more than 780 TV episodes and 13 movies after its first broadcast in the UK in 1969.
The set comprises 12 stamps depicting the captains from the six main TV series, plus additional crew members: Captain James T Kirk, Spock, Captain Jean-Luc Picard, Commander Deanna Troi, Captain Benjamin Sisko, Doctor Julian Bashir, Captain Kathryn Janeway, Captain Jonathan Archer, Lieutenant Malcolm Reed, Captain Gabriel Lorca, Lieutenant Ash Tyler and Commander Michael Burnham.
A further six stamps, presented in a miniature sheet, feature characters from across Star Trek movies, all played by British actors: Montgomery Scott, Shinzon, Tolian Soran, Klingon Chancellor Gorkon, Carol Marcus, and Krall.
Philip Parker of Royal Mail, said: “For more than 50 years Star Trek has enthralled and inspired generations of loyal fans with extraordinary adventures and an optimistic vision of humanity’s future.
“We celebrate the Star Trek Universe with stylish new stamps of its iconic characters.”
The 12 main character stamps are new illustrations by London-based artist Freya Betts.
The images portray the characters alongside reflective details, including starships, in the background of their respective series.
The stamps are on sale on November 13.