Covid: New variant with potentially troubling mutations discovered in UK

A report from Edinburgh University said there are 33 cases so far involving B.1.525 in samples dating back to December. Credit: PA

Scientists have found another new Covid-19 variant which has potentially troubling mutations.

The variant is known as B.1.525. It contains a genetic change called E484K, also found in the Brazilian and South African variants.

Public Health England (PHE) has said there is no evidence that the mutations in the new variant make the virus more transmissible or cause severe disease.

ITV News Science Editor Tom Clarke explains how different Covid variants are evolving in similar ways, but separately

Laboratory studies have shown that viruses with the E484K mutation can escape human defences, making them more efficient at evading natural and vaccine-triggered immunity.

A report from Edinburgh University said there are 33 cases so far involving B.1.525 in samples dating back to December.

New variants of concern in the UK

  • B.1.525 - 33 cases

  • South African variant - 202 cases

  • Bristol variant - 22 cases

It has also been seen in other countries, including Australia, Denmark, Nigeria and the US.

Professor Yvonne Doyle, PHE medical director, said: “PHE is monitoring data about emerging variants very closely and where necessary public health interventions are being undertaken, such as extra testing and enhanced contact tracing.

Credit: PA

“There is currently no evidence that this set of mutations causes more severe illness or increased transmissibility.

“The best way to stop the spread of the virus is to follow the public health advice – wash your hands, wear a face covering and keep your distance from others.

“While in lockdown, it is important that people stay at home where possible.”

The experts said the variant has alterations in its genetic material that make it similar to the Kent variant, which is now the dominant virus in the UK.

Dr Simon Clarke, an associate professor of cellular microbiology at the University of Reading, told the Guardian that the presence of the E484K mutation was known in the South Africa variant to confer a degree of resistance to some vaccines.

He said: “We don’t yet know how well this (new) variant will spread, but if it is successful it can be presumed that immunity from any vaccine or previous infection will be blunted.”

Dr Clarke said B.1.525 should be included in efforts to boost testing to pick up variants of concern.

A couple wearing protective face masks Credit: Jane Barlow/PA

He said: “I think that until we know more about these variants, any variants which carry E484K should be subject to surge testing as it seems to confer resistance to immunity, however that is generated.”

Other new variants of concern in the UK include the South African variant, with 202 cases, and the Bristol variant, with 22 cases detected.

A variant first identified in Liverpool, which has been dubbed by the PHE as variant under investigation (VUI), currently has 56 cases.

Scientists are already working on new vaccines to target coronavirus variants, some of which may become available during the autumn.

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