Covid: 'Mix and match' coronavirus vaccine trial expanded to include Moderna and Novavax jabs

Video report by ITV News Video Producer Natalia Jorquera

A study looking at whether the Oxford/AstraZeneca and Pfizer/BioNTech Covid-19 vaccines can be safely mixed for the first and second doses will be expanded to include two additional jabs.

Researchers running the Com-Cov study, launched in February to investigate alternating doses of the first two coronavirus jabs to be rolled out across the UK, have announced the programme will be extended to include the Moderna and Novavax vaccines.

The Moderna jab has started being rolled out across the UK, and the Novavax jab manufactured by GlaxoSmithKline (GSK) is under rolling review by the Medicines and Healthcare products Regulatory Agency (MHRA).

Led by the University of Oxford, the extra study will seek to recruit adults aged over 50 who have received their first vaccination in the past eight to 12 weeks.



Matthew Snape, associate professor in paediatrics and vaccinology at the University of Oxford and the trial's chief investigator, told Times Radio: “The main drive behind this study is to increase the flexibility of the UK’s schedule and resilience in the case of problems with supply or availability of any of the vaccines.”

He added: “We want to know, if you do give different vaccines for first and second dose, are the immune responses as good as if you’re giving the same vaccines?

“We know that when you give the same vaccine for the first and second dose, we get very good protection against Covid-19.

“And we’re going to be looking to see if the immune response and the profile and reactions after the vaccines are as good if you’re mixing the vaccines, which would greatly increase flexibility.”

The researchers will study any adverse reactions and the immune system responses to these new combinations of vaccines.

The study is designed as a so-called non-inferiority study, which means its intent is to demonstrate that mixing is not substantially worse than not mixing.

It will compare the immune system responses to the gold-standard responses reported in previous clinical trials of each vaccine.

If the study shows promising results, the MHRA and Joint Committee on Vaccination and Immunisation would formally assess the safety and efficacy of any new vaccination regimen before it is rolled out to patients.

The study is looking to recruit 1,050 new volunteers. Credit: PA

Matthew Snape, associate professor in paediatrics and vaccinology at the University of Oxford, who is chief investigator on the trial said: “The focus of both this and the original Com-Cov study is to explore whether the multiple Covid-19 vaccines that are available can be used more flexibly, with different vaccines being used for the first and second dose.

“If we can show that these mixed schedules generate an immune response that is as good as the standard schedules, and without a significant increase in the vaccine reactions, this will potentially allow more people to complete their Covid-19 immunisation course more rapidly.

“This would also create resilience within the system in the event of a shortfall in availability of any of the vaccines in use.”

The volunteers, who will have received either the Oxford/AstraZeneca, or Pfizer/BioNTech vaccine, will be randomly allocated to receive either the same vaccine for their second dose, or a dose of the jabs produced by Moderna or Novavax.

The six new arms of the trial will each recruit 175 candidates, adding 1,050 recruits into this programme.

Ellie Taylor became the first person in the UK to get a Moderna vaccine last week. Credit: Jacob King/PA

Prof Snape said he hoped the results of the second part of the study would be available in June or July, with the first part expected to report results next month.

He told a press briefing: “What I’m hoping is that we won’t rule out any combinations.

“That’s how we need to look at it – are there any combinations we shouldn’t be giving, because they don’t generate a good immune response and I’m hoping that won’t be the case.

“And that will give us lots of flexibility, not just in the UK, not just in Europe where we’re looking about restricting uses of some vaccines for some age groups, but across the world, where we have, perhaps, a little bit more intermittent supply of vaccines, not as reliable.

“But let’s hope that we can actually use this to get two doses of vaccine to as many people as possible.”

The study is being run across nine National Institute for Health Research-supported sites by the National Immunisation Schedule Evaluation Consortium, and backed through funding from the Vaccines Taskforce and the Coalition for Epidemic Preparedness Innovations.

Professor Jeremy Brown, a member of the Joint Committee of Vaccination and Immunisation, said people will eventually “have to” mix Covid-19 jabs.

He told BBC Radio 4’s Today programme: “It’s practically going to have to be that way because, once you’ve completed a course of, say, the Moderna or Pfizer or the AstraZeneca with two doses, in the future it’s going to be quite difficult to guarantee you get the same type of vaccine again.

“So there will be a mix-and-match occurring just by the sort of practicalities of doing a third or fourth vaccination over the next few years…

“Getting data on that is important so there are trials at the moment about the immunological responses to the mixed-vaccine combinations.”


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