The Duke and Duchess of Sussex met with Deputy Secretary-General Amina Mohammed at the UN headquarters, before they later attend the star-studded Global Citizen show in New York.
“It was a lovely meeting,” Meghan said as the couple left the UN headquarters.
Ms Mohammed said she has been speaking to Harry and Meghan about the issue of vaccine equity among other topics they “care about deeply”, including climate action and mental health.
The couple were pictured in front of the UN logo alongside Ms Mohammed on Saturday, with Meghan wearing a beige blouse and trousers with an auburn jacket, and Harry wearing a black suit and blue tie.
Ms Mohammed, the former environment minister for Nigeria, shared the picture in a tweet, saying: “In conversation with the Duke and Duchess of Sussex.
“Sharing how to engage on issues we care about deeply: climate action, women’s economic empowerment, mental well-being, youth engagement and vaccine equity.”
The UN is hosting the 76th General Assembly, which has been attended by global leaders including Prime Minister Boris Johnson.
The meeting came ahead of their attendance at Global Citizen Live, which is being staged in Central Park and around the world, calling on leaders to adopt a vaccine equity policy.
Meghan and Harry are set to speak on the issue during the star-studded, 24-hour concert.
It is one of several shows being held in cities from London to Lagos by the organisation Global Citizen, with artists including Ed Sheeran, Sir Elton John, Kylie Minogue, Metallica and Coldplay scheduled to perform.