National action to disrupt drug dealing known as 'County lines' has led to more than 200 arrests and safeguarding of 58 vulnerable people.
It came after a week of action which has also seen weapons such as hunting knives, firearms and swords being seized.
Significant amounts of heroin and crack cocaine along with other illegal drugs were also seized.
The crackdown was overseen by the new National County Lines Coordination Centre, led by the National Crime Agency and the National Police Chiefs Council.
County lines is the name given to urban drug dealers who expand their dealing into smaller towns and rural areas.
It usually involves the use of a single phone line to communicate with drug users.
There are thought to be approximately 1500 lines in operation in the UK.
Across Norfolk, Suffolk and Essex 65 people were arrested as part of the week long operation, half of those were in Norfolk with 33 arrests. There were 19 in Suffolk and 13 in Essex.
In Bedfordshire there were four arrests and a significant amount of cash and drugs were seized and in Cambridgeshire there were nineteen arrests.