The Sick Children's Trust is warning that every room it offers at hospitals in the Anglia region will be full over the festive season.
It costs £30 to look after a family of a sick child for the night. The charity hopes to raise £13,000 to fund its ten houses over the holidays.
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The Sick Children's Trust provides accommodation for parents on the Addenbrooke's site.
Christina Mitcham can spend an extra two hours a day with her son Charlie instead of in the car.
She said: "It's just like you can use it as your own house, you can come and go and within minutes you can be by their bedside which helps them get better quicker."
It costs £30 to look after a family for the night. The charity hopes to raise £13,000 to fund its ten houses over the holidays.
Sandra Peckham, from the Sick Children's Trust, said: "No child should wake up alone on Christmas morning.
"It's so important to the Sick Children's Trust to keep all the families together but sadly every day children are diagnosed with life-threatening conditions or are faced with accidents.
"It's important for the families to be here and to be close to them."
Emily and Chris James are back in their own home in Cambourne after a stay at the charity's Chesnut House. Their son Harvey was starved of oxygen for several minutes when he was born.
He was rushed to Addenbrooke's and given a lifesaving cooling treatment.
Seven days later Emily was able to hold him for the first time.
She said: "We could also go up late at night and say goodnight to him which was really nice.
"I think if we were having to come home each night I'd find it even harder - not that it was easy, but the fact that we were there and could be there immediately for him."
Harvey has now been discharged from Addenbrooke's and they can can all look forward to his very first Christmas.