The A1 near Stamford was closed for nearly 12 hours on Friday after a tanker carrying more than 20 tonnes of sulphuric acid overturned.
The incident happened just after 5am.
Police said the lorry was found on its side, but luckily no acid leaked onto the road.
Specialist teams spent much of the day trying to move the vehicle, and the road eventually reopened in both directions shortly before 5pm.
“There are no injuries to the driver as far as I am aware," Mark Gee from Lincolnshire Police said.
"The driver was trapped initially but managed to get himself out."