Ryanair is investing more than £200 million in creating a new base at Southend Airport.
The low-cost airline says three planes will offer around 63 flights a week to eight European countries.
Ryanair says it will create 750 jobs and carry at least one million passengers in the first year.
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The Ryanair destinations include Alicante, Barcelona Reus, Bilbao, Brest, Copenhagen, Corfu, Cluj, Dublin, Faro, Kosice, Malaga, Milan Bergamo, Palma and Venice.
The airport also has flights with airlines like EasyJet and Flybe and it aiming to reach two million passengers per year by 2020.
Southend airport, which is owned by Stobart Group, says expansion there will help ease pressure on other London airports.