Forty years ago, Natasha Rogers was considered a medical marvel after she survived being born with a hole in her heart. Her parents were told she may not live past one.
She had a heart and lung transplant in her 20s and despite doctors telling her parents she wouldn't live for long, she's still here.
After beating the odds so many times before, now the 44-year-old from Northampton faces yet another challenge. Her kidneys are failing.
But Natasha still isn't giving up. Her life has been a testament to medical advances over the last four decades and, this time, it's her sister Hayley who will save her life by donating a kidney
- Click to watch a report by ITV News Anglia's Graham Stothard