The Orwell Bridge near Ipswich is to close from 5pm (Tuesday 14th January) to the early hours of Wednesday morning due to high winds.
It's the second consecutive night the bridge has been closed.
Highways England says it will continue to monitor wind speeds closely during the ten hour closure, before making a decision about when exactly to re-open the A14 bridge.
However the bridge is expected to re-open at 3am.
A diversion route will be in place via A1156 - A1189 - A1214 through Ipswich
Highways England told ITV News Anglia that it has been working with experts to see if vehicles can 'safely' be allowed over Orwell Bridge during high wind speeds.
It comes over concern that the continued closure of the bridge causes grid-lock in and around Ipswich, affecting the local economy.
“We are always looking for ways to improve the resilience of our road network and over the last 12 months we have been working with our partners in Suffolk and City University of London to see if we can safely allow vehicles over Orwell Bridge during higher wind speeds.
Winds are expected to reach up to 60 mph in places across the region with a minimum of 40 - 50 mph.