Fifteen people have died at Castletroy Care Home in Luton.
Public Health England have confirmed five of those who died had coronavirus - the other ten were not tested.
The residential home in Cromer Way has 69 beds for elderly people with nursing or personal care needs.
In a statement read outside the home, Chloe Messon said: "Our teams remain committed to provide the best of care and continue to follow advice and guidance to contain the spread of infection."
- Watch a report by ITV News Anglia's Matthew Hudson
It comes as the UK recorded its highest number of Covid-19 deaths on Wednesday but those figures only include deaths in hospital, not those in care homes or in the community.
The care home has closed its doors to visitors for the time being.
In a statement Public Health England said: “Public Health England East is working closely with staff and residents at Castletroy Care Home, Luton Council and other local partners, following the deaths of 15 residents.
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