Wizz Air has resumed some flights out of Luton Airport.
The low-cost airline said it has restarted selected flights with "enhanced" health and safety measures due to the coronavirus pandemic.
They initially plan to operate 10% of scheduled flights for passengers who have essential journeys.
Despite the airline's move, the government is still advising people not to travel abroad.
Cabin crew will be required to wear masks and gloves on all flights and willdistribute sanitising wipes for passengers, the airline said in a statement.
"The safety of our passengers and staff is our top priority and we continue to rigorously implement all Government guidance. This includes deep cleaning, the installation of sanitiser across the airport and floor markings and signage to remind customers to maintain a safe distance. We are also displaying the latest public health guidance throughout the terminal.
Air links for both passengers and freight have been recognised as essential services and the Government has asked airports to remain open where possible, to ensure they can continue. The decision to operate individual routes is a matter for each airline. As well as adhering to travel restrictions in the country of travel, passengers also need to follow those imposed in the UK.”
New distancing measures will also be introduced during boarding and the aircraft will be disinfected overnight.
From May 1, flights will resume to selected airports in Hungary, Romania, Serbia, Slovakia, Portugal, Spain and Israel.
Owain Jones, Wizz Air UK's managing director, said the health, safety and well-being of customers and staff is their primary concern.
"The protective measures that we are implementing will ensure the most sanitary conditions possible", he said.
"We encourage our customers to watch our new video on how to stay safe when travelling, as well as for more details on our new health and safety measures."
Customers will be asked to check in and make any additional payments for services - such as additional bags - online to reduce physical interaction at the airport.
Passengers will also be "encouraged" to make any on-board purchases using contactless payment methods.