The Dogs Trust which has centres in Snetterton in Norfolk and Basildon in Essex is warning there could be a surge in abandoned pets because of coronavirus.
The charity is estimating as many as 40,000 dogs could be given up as families face financial hardship.
Euthanasia rates could also increase by up to 25% in the next year as was seen in 2009 following the recession - meaning over 1,800 dogs in local authority shelters could be put to sleep unnecessarily.
The demand for puppies soared during lock down with web searches for puppies up 166%.
The Dogs Trust is also now caring for a number of dogs whose owners have passed away from coronavirus or contracted the virus and are no longer able to care for pets.
Now the charity is launching an urgent fundraising appeal to help care for the dogs who might need them in the future.