Loganair will operate the first commercial and business passenger flights from Carlisle Lake District Airport since 1993.
The Scottish airline will run flights to the south of England, Northern Ireland and Republic of Ireland from 4 June.
One-way ticket prices will begin at £44.99 - a full timetable is listed below.
There will be eight flights per day across the working week and a total of 12 at weekends, connecting Cumbria and the Lake District, which receives 45 million visitors per year, to London Southend Airport, Belfast City Airport and Dublin Airport.
Tickets will go on sale from Monday 12 March.
Stobart Group, which runs the airport, says there will be "huge demand" for the flights.
Cumbria Tourism has also welcomed the news. The group says it could result in people spending longer in Cumbria and the Lake District.
- Summer 2018 timetable & Fares – from 4 June 2018
London Southend to Carlisle Lake District Airport:
Mon-Thu Dep 06:50 Arr 08:15
Fri-Sun Dep 11:35 Arr 13:00 Mon-Thu Dep 17:20 Arr 18:45 Fri & Sun Dep 18:00 Arr 19:25
Mon-Thu Dep 08:45 Arr 10:05 Fri-Sun Dep 13:30 Arr 14:50 Mon-Thu Dep 19:15 Arr 20:35 Fri & Sun Dep 19:55 Arr 21:20
Fares from Carlisle Lake District to London Southend start at £44.99 one-way including all taxes and charges. All Loganair fares include a 20kg checked baggage allowance and complimentary in-flight refreshments.
Dublin to Carlisle Lake District
Fri-Sun Dep 08:00 Arr 09:15 Mon-Thu Dep 13:40 Arr 14:55
Fri-Sun Dep 09:45 Arr 11:00 Mon-Thu Dep 15:25 Arr 16:40
Fares from Carlisle Lake District to Dublin start at £44.99 one-way including all taxes and charges, and from Dublin to Carlisle Lake District at €44.99 one-way.
Belfast City to Carlisle Lake District
Mon-Thu Dep 10:45 Arr 11:35 Fri & Sun Dep 15:25 Arr 16:15
Mon-Thu Dep 12:05 Arr 12:50 Fri & Sun Dep 16:45 Arr 17:30