Railway passengers are being urged to plan ahead, as the West Coast Mainline route is set to be closed on Easter Sunday, 1 April.
The service, which is operated by Virgin Trains, connects Scotland and Cumbria to London Euston.
However, passengers have been told to travel on alternative days, to avoid being caught out by the closure.
Services on Saturday 31 March and Monday 2 April are also expected to be busier than normal, as fewer trains will be running.
The disruption is part of Britain's Railway Upgrade Plan, and involves Network Rail engineers doing preparatory work to enable the replacement of north Wembley junction in August.