Train services have been cancelled and some roads are blocked as the region is hit by heavy rain for the third time in two weeks.
17 flood alerts and five flood warnings have been issued by the Environment Agency across Cumbria and Southern Scotland, as recovery efforts continue following Storm Dennis.
A number of yellow weather warnings have been put in place by the Met Office across the UK, with persistent rain likely to continue until about 3pm.
Shap, in Cumbria, which recorded 120mm across February 2019, saw 52mm fall in less than six hours.
Trains were temporarily cancelled between Carlisle and Preston on the West Coast Mainline due to heavy flooding.
A bus replacement service is running for travellers who have been affected by the disruption. Network Rail says passengers are to expect a 30-minute delay to their journeys and some cancellations.
The Cumbrian coast line is be reported to be blocked at Wigton, and Northern Trains says passengers should check before travelling.
Some roads in the region affected by flooding:
- The A684 is blocked in both directions at Ingmire Hall, between Sedbergh and the M6, because of standing water.
- Rickerby Park from Brampton Road due to likelihood of the River Eden flooding.
- Flooding on A592 between Newby Bridge and Windermere in several places.
- B6413 impassable, near Talkin Level Crossing, between Brampton and the Talkin village turn off.
Other areas of travel have also been disrupted including the Windermere Ferry which is temporarily out of service until further notice due to high lake levels.
The region was hit by severe flooding last week as two storms swept the country. Storm Ciara and Storm Dennis brought heavy rain and gale force winds and left a whole village in the Scottish Borders underwater.
One man described the flooding in Newcastleton as "armageddon", with more than 80 homes in the area submerged after the Liddell Water burst its banks on Saturday evening.
- Stay up to date with all the latest weather news and travel disruption on ITV Border.