Teaching staff are among those staging a 14 day walk-out at the University of Glasgow's Dumfries Campus.
It's over a long-running dispute over pay, pensions and working conditions.
University UK has called for the union to continue talks, but those on taking part in the protest say they've faced a 20% pay cut in real terms since 2009.
Natalie Welder, who is a lecturer at University of Glasgow at the Dumfries campus, said: "I hope that the action will be incredibly short and our employers will come together to make real changes across our industry.
"Obviously, I feel for all our students at the moment but really we're thinking about their futures as well.
"Hopefully some of them will go to the positions that we're in and we want to make sure there's an industry they want to work in the future."
A Universities and Colleges Employers' Association spokesman said universities were "deeply disappointed" that the strikes were going ahead.
They will largely take place between this Thursday and Friday, Monday and Wednesday next week as well as on March 2, 5, 9 and 13.