The A69 has fully re-opened following its closure due to hazardous driving conditions.
Police and other agencies have been working overnight to re-open the road.
Motorists are still advised to only travel if necessary.
The A69 is closed both ways near Low Row because of an accident involving two vehicles between Lanercost Turn and East of Low Row.
Drivers are asked to avoid the area.
A 30-year-old man has been taken to hospital with non-serious head injuries following a two-vehicle crash on the A69.
Emergency services were alerted to the incident near Low Row, Carlisle between the A689 and the Denton Mill turn-off at 1.30pm.
The occupants of the second vehicle are not believed to be injured.
All lanes have now been re-opened.
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The A69 is closed in both directions near Carlisle due to accident investigation work.
SEVERE A69 closed in both directions between Carlisle and the A689 junction in Brampton, because of accident investigation work.
Cumbria Police have named a 92-year-old female pedestrian killed in a collision on the A69 near Carlisle.
Eva Rigg, of Aglionby, was involved in a collision with a Honda CBF 1000 motorcycle near her home at around 5pm on 14 December.
Eva Rigg was pronounced dead at the scene, and the motorcyclist, a 65-year-old man from Carlisle, was taken to the Cumberland Infirmary with minor injuries.
The road was closed whilst forensic collision investigation work was carried out.
Anyone who witnessed the collision or stopped after the collision at the scene is asked to call 101.
Police are warning drivers of delays on the A69, towards Gretna, as they escort a slow-moving abnormal load this afternoon.
The load will be leaving the M6 north at junction 45, heading towards Gretna via the A689.
Police say there will be a number of slow-moving loads following the same route over the coming days apart from Saturday.
The A69 Eastbound has been closed due to a chemical incident between the A6079 and A68 / B6529 Stagshaw Road (Stagshaw Roundabout).
It's resulting in delays to traffic heading from Cumbria towards Newcastle.
The incident happened on the Bridge End Roundabout, and is particularly affecting traffic heading between Haydon Bridge and Corbridge.
Diversions are in place via the A6079, B6318 and A68.
A four-year-old girl is in a serious condition in hospital after the car she was travelling in was involved in a crash on the A69.
The two-vehicle collision happened between Brampton and Corby Hill at 8.45am.
A 43-year-old woman from Carlisle, who was driving the Vauxhall Astra, was also taken to the Cumberland Infirmary with serious, but not life-threatening, injuries.
A 46-year-old male driver of a Land Rover, also involved in the crash, did not suffer any injuries.