The A69 Eastbound has been closed due to a chemical incident between the A6079 and A68 / B6529 Stagshaw Road (Stagshaw Roundabout).
It's resulting in delays to traffic heading from Cumbria towards Newcastle.
The incident happened on the Bridge End Roundabout, and is particularly affecting traffic heading between Haydon Bridge and Corbridge.
Diversions are in place via the A6079, B6318 and A68.
A four-year-old girl is in a serious condition in hospital after the car she was travelling in was involved in a crash on the A69.
The two-vehicle collision happened between Brampton and Corby Hill at 8.45am.
A 43-year-old woman from Carlisle, who was driving the Vauxhall Astra, was also taken to the Cumberland Infirmary with serious, but not life-threatening, injuries.
A 46-year-old male driver of a Land Rover, also involved in the crash, did not suffer any injuries.
The A69 has now re-opened following a crash which happened between Brampton and Corby hill at 8.45am.
Police were called to the two vehicle collision involving a Landrover and a Vauxhall Astra.
Police are warning drivers in Cumbria to expect delays between Carlisle and Blenkinsopp tomorrow.
From around 9am police will escort a slow moving abnormal load via the A689 into Crosby Village and onto the A69.
Delays are expected until around 1pm.
Roads Minister Andrew Jones says there is a "national pinch point" between Cumbria and the North East when it comes to road transport.
He's in Carlisle today, to look at plans to turn two major Cumbrian roads, the A69 and A66, into dual carriageways:
The key thing here is we know we have a national pinch point. We want to improve the east to west connections in the north of our country.
And how do we do that is the question we've asked. And we've asked it in a strategic study, which is going to report next year, and that will form part of our thinking in how we construct future road investment schemes."
A woman in her eighties was woken in the early hours of this morning to discover a lorry had crashed into her house.
Helen Walker, a family friend of the 85 year old has described the moment her neighbour's house was hit.
Police were called at 3.16am today following a one vehicle collision on the A69 near Little Corby.
A HGV hit a house and a lamppost. The driver was a 50 year old man from Carlisle.
No one was injured in the incident and the road was reopened at around 8.20am.
A lorry crashed into a house near the crossroads in Corby Hill, next to the Brampton Medical Practice around 3am this morning.
It hit the house of a lady in her eighties while she was sleeping in her bedroom downstairs.
Damage was made to the lady's bedroom windowsill as well as the house's gutters.
The lorry then went on to wipe out a street light and a bus station.
The A69 in Cumbria has been closed this morning after a lorry crashed into a house, strewing masonry and debris across the carriageway.
It happened just after 3am at the crossroads in Corby Hill, next to the Brampton Medical Practice.
Police confirmed that the driver of the truck escaped serious injury.
The truck came to rest in the front garden of the house involved.
The road has remained closed as clear up work is carried out and diversions have now been set up between junction 43 of the M6 and the A689 at Brampton.
With roadworks set to take place on two major roads into Carlisle, Ryan Dollard has been to find out what drivers in the area think: