An elderly couple are in a serious condition in hospital after two vehicles were involved in a crash on the A66.
The accident happened at Small Ways in County Durham around 12:45pm this afternoon.
The two elderly people were flown by air ambulance to the James Cook University hospital in Middlesborough with multiple injuries.
The two people in the other vehicle were taken to a hospital in Darlington.
The road has been closed for several hours.
The A66, the main road connecting the North West with the North East, has re-opened.
It was closed in both directions on Christmas morning, between County Durham and Cumbria, after a spate of accidents caused by black ice.
Police are urging motorists to continue to drive with care.
The A66, one of the north's main roads, has been closed because of "severe ice".
Police say the move follows a series of accidents on Christmas morning.
The road connects the North West with the North East, and has been closed in both directions between Bowes in County Durham and Cumbria.
Low overnight temperatures have left ice and black ice as driving hazzards across the north and police are urging motorists to slow down, and to drive with care.