The A69 is closed both ways near Low Row because of an accident involving two vehicles between Lanercost Turn and East of Low Row.
Drivers are asked to avoid the area.
A 30-year-old man has been taken to hospital with non-serious head injuries following a two-vehicle crash on the A69.
Emergency services were alerted to the incident near Low Row, Carlisle between the A689 and the Denton Mill turn-off at 1.30pm.
The occupants of the second vehicle are not believed to be injured.
All lanes have now been re-opened.
Slow traffic and partially blocked due to accident involving two lorries on the A69 in both directions at Low Row Service Station.
Emergency services are on the scene dealing with the incident - affecting traffic towards Scarrow Hill. Police are directing traffic.