The B5305 is blocked in both directions at Sebergham, Cumbria, as a lorry has jacknifed on Sebergham Bridge.
Delays between Wigton and Penrith can be expected and police say the road will not be clear until at least 10am.
Burton Road on the A65, near Kendal, is partially blocked in both directions due to an accident involving two vehicles at Oxenholm Lane.
The A7 Eden Bridge southbound is partially blocked near to Carlisle Cricket Club due to an accident involving two cars at Brampton Road.
There are reports that Station Road in Wigton is partially blocked due to a lorry colliding with a bridge between New Street and the A596.
Police are en-route.