The A66 has been closed at Threlkeld following a collision involving a car and a cyclist.
Emergency services are currently at the scene at the junction with Threlkeld, near Keswick.
The extent of the cyclist's injuries are not known at this time.
Motorists are being advised to avoid the area and to seek alternative routes.
A cricket club in Cumbria, whose pitch was destroyed by flooding in June, has suffered another setback. The club, at Threlkeld near Keswick, has found out that the ground is contaminated by lead and arsenic from the flood water.
The clean up is now likely to take longer, be more expensive and there's an argument over who should pay the bill.
Threlkeld cricket club's pitch is officially contaminated, according to a report commissioned by the England and Wales Cricket Board.
The pitch, which was once named one of the prettiest clubs by cricket almanac Wisden, was destroyed by flooding and hundreds of tonnes of rubble last month.
The club estimates that the flooding and cost of the damage is about £100,000.
Carlisle MP John Stevenson has said that the Environment Agency will be assessing how well the new flood protection system in the city faired in its first big test.
The MP said he was pleased with how well it appeared to cope in the face of some of the worst rain in a single day since 2005.