The A66 has been closed at Threlkeld following a collision involving a car and a cyclist.
Emergency services are currently at the scene at the junction with Threlkeld, near Keswick.
The extent of the cyclist's injuries are not known at this time.
Motorists are being advised to avoid the area and to seek alternative routes.
More top news
Officers became aware of a video circulating online by a child sexual exploitation activist group.
Watch Wednesday's Representing Border
All of those who died had tested positive for the virus, although some had other severe health issues.