First Minister Nicola Sturgeon has welcomed Scotland's "unequivocal" vote to stay in Europe.
But despite the vote, the country still faces the prospect of leaving the EU, after the Leave campaign edged ahead across the UK.
The result means Ms Sturgeon will now come under pressure to call a second independence referendum.
She said the vote made it clear that "the people of Scotland see their future as part of the European Union."
"We await the final UK-wide result, but Scotland has spoken - and spoken decisively."
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Jamie Reed MP has said that "...many people have voted to make their lives worse because they don’t believe that life can get better."
Although a majority across the south of Scotland wanted to remain, only one area of Cumbria wanted to stay within the EU.