The A66 is closed near Workington after a serious crash involving a HGV and a car.
The collision happened at Stainburn at around 7.20am this morning.
There's believed to be one casualty - the male driver of the Ford Focus car.
The road is closed in both directions between the Stainburn roundabout, along the Great Clifton bypass, to the A595 Bridgefoot roundabout.
The road is expected to remain closed for the rest of the morning.