The M62 near Goole is closed in both directions following a major accident between junctions 36 and 37.
It happened at around half past nine this morning when police say a lorry which was travelling westbound went through the central reservation and collided with an oncoming car heading eastbound.
There are huge traffic jams and motorists are being urged to avoid the area.
Both carriageways are closed while emergency crews are on the scene. They are expected to remain shut for the most of the day.