Judith Blake, leader of Leeds City Council, is coming together along with Andy Burnham and Steve Rotheram, the mayors of Manchester and Liverpool, to make sure their areas are not forgotten in the row over exiting the EU.
The trio, who together represent major communities that make up 15 million people, are meeting today in Sheffield for the Transport for the North (TfN) inaugural conference.
There they will launch the Strategic Transport Plan (STP) that was agreed last week, which sets out a £70 billion investment programme over the next 30 years which is claimed "could unlock £100 billion in economic growth and create one million jobs".
It makes the case to increase spending on strategic transport by around £50 per person in the north each year to 2050. Other plans include upgraded and new major roads, enhancements to the existing rail network, and the continued roll-out of smart ticketing.
Ms Blake said the north has been shut out of the major Brexit decisions, adding: "It simply cannot be allowed to go on any longer.
"One small way for politicians at Westminster to show that it won't be business as usual, would be for them to take these plans forward in full."