Victor Valdes made his full Manchester United debut as Louis van Gaal's side looked to send Hull down with victory at the KC Stadium.
David de Gea failed to overcome his hamstring injury and was left out of the squad, which meant Valdes made his first start since suffering a serious knee injury for Barcelona 14 months ago.
Angel di Maria replaced Marouane Fellaini in midfield and captain Wayne Rooney came in for Radamel Falcao, who did not make the bench.
Hull, who must win to stand any chance of avoiding relegation, named the same starting XI that lost to Tottenham last weekend.
A goalless draw at home to Manchester United condemned Hull to the Championship next season.
Hull City must beat Manchester United today and hope Newcastle drop points against West Ham to avoid relegation from the Premier League